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A complete of three % of Lively substance is excreted in urine as unchanged Energetic compound. Tapentadol is Also metabolised to N-desmethyl tapentadol (thirteen %) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (2 %) by CYP2D6, that are even further metabolised by conjugation. For that reason, Lively substance metabolism mediated by cytochrome P